Our Research
Beyond their traditional role in host defense, cells of the immune system have unique roles in regulating tissue homeostasis, function, and repair. Multiple types and flavors of immunocytes work together to coordinate tissue repair and regeneration. These cells communicate with the tissue and rely on tight spatiotemporal regulation to coordinate an appropriate response. Our lab’s main goal is to dissect and engineer immune-regulatory mechanisms of regenerating tissues. We use a systems immunology approach that integrates single-cell methods, spatial omics, machine learning, and cutting-edge in vivo genetic tools to uncover fundamental mechanisms of tissue regeneration. Ultimately we aim to translate these fundamental insights to engineer precision therapeutics that enhance and accelerate tissue healing and drive innovations in regenerative medicine for improved health outcomes.
The myometrium, the muscle layer in the uterus, is a remarkably regenerative tissue. It also harbors a very unique population of immunocytes, including regulatory T cells (Tregs), that support fetal development and birth. We are studying the T cell populations in the myometrium to understand how they contribute to the incredible regenerative ability of the myometrium. We aim to uncover novel immunotherapies to improve women’s health.
Tissue regeneration is a spatiotemporally complex that requires tight coordination between multiple cells. This regulation is mediated by extensive communication networks between immunocytes, progenitor/stem cells, stromal cells, and parenchymal cells. We exploit systems immunology approaches to dissect these communication mechanisms underlying tissue regeneration.
What do T cells recognize in injured tissues? Does the injury change the T cell response? Can we exploit these injury-sensing mechanisms to design new therapies? We use a combination of cutting-edge experimental and computational tools to engineer T cell therapies to improve the regenerative capacity of injured and diseased tissues.